Cars had a highly successful run during the 2006 awards season. Many film critic associations such as the Broadcast Film Critics Association and the National Board of Review named it the best Animated Feature Film of 2006. Cars also received the title of Best Reviewed Animated Feature of 2006 from Rotten Tomatoes. Randy Newman and James Taylor received a Grammy Award for the song "Our Town," which later went on to be nominated for the Academy Award for Best Original Song (an award it lost to "I Need to Wake Up" from An Inconvenient Truth). The film also earned an Oscar nomination for Best Animated Feature, but it lost to Happy Feet. Cars was also selected as the Favorite Family Movie at the 33rd People's Choice Awards. Perhaps the most prestigious award that Cars received was the inaugural Golden Globe Award for Best Animated Feature Film. Cars also won the highest award for animation in 2006, the Best Animated Feature Annie Award.

The film was also nominated for AFI's 10 Top 10 in the "Animation" genre.^[21