Cars was released on DVD in both wide-screen and full-screen editions on October 25, 2006 in Australia and New Zealand, on November 7, 2006 in the United States and Canada, and on November 27, 2006 in the United Kingdom. It includes DVD-exclusive short film Mater and the Ghostlight and the film's theatrical short One Man Band, as well as Inspiration for Cars, a 16 minute long documentary about Cars featuring John Lasseter, the director. It also had a version of the Pixar short Boundin' as an Easter Egg.

According to the Walt Disney Company, five million copies of the DVD were sold in the first two days it was available.^[22] In its first week it sold 6,250,856 units and 15,370,791 units in total ($246,198,859).^[23]

Unlike previous Pixar DVD releases, there is no two-disc special edition, and no plans to release one in the future. According to Sara Maher, DVD Production Manager at Pixar, John Lasseter and Pixar were preoccupied with productions like Ratatouille.^[24] Additional extras not seen on the DVD have since been released on the official DVD website.^[25]

In the US and Canada, there were bonus discs available with the purchase of Cars at Wal-Mart and Target. Wal-Mart featured a Geared-Up Bonus DVD Disc that focused on the music of the film, including the "Life Is A Highway" video, The Making of "Life Is A Highway", Cars: The Making of the Music, and Under The Hood (a special that originally aired on the ABC Family cable channel). Target's bonus was a Rev'd Up DVD Disc that featured material that was mostly already released as part of the official Cars podcast and focused on the inspiration and production of the movie.

Cars was also released on Blu-ray Disc on November 6, 2007.